LymphedemaV1, Main, Exploration, bibRecord, 004B68

Role of bone marrow-derived lymphatic endothelial progenitor cells for lymphatic neovascularization

Identifieur interne : 004B68 ( Main/Exploration ); précédent : 004B67; suivant : 004B69

Role of bone marrow-derived lymphatic endothelial progenitor cells for lymphatic neovascularization

Auteurs : Changwon Park ; Ji Yoon Lee ; Young-Sup Yoon

Source :

Trends in Cardiovascular Medicine [ 1050-1738 ] ; 2011.

RBID : PMC:3384483

Descripteurs français

KwdFr :
- Cellules de la moelle osseuse (cytologie), Cellules endothéliales (physiologie), Cellules souches (physiologie), Glycoprotéines membranaires (métabolisme), Humains, Néovascularisation pathologique (physiopathologie), Vaisseaux lymphatiques (physiologie).
MESH :
- cytologie : Cellules de la moelle osseuse.
- métabolisme : Glycoprotéines membranaires.
- physiologie : Cellules endothéliales, Cellules souches, Vaisseaux lymphatiques.
- physiopathologie : Néovascularisation pathologique.
- Humains.

English descriptors

KwdEn :
- Bone Marrow Cells (cytology), Endothelial Cells (physiology), Humans, Lymphatic Vessels (physiology), Membrane Glycoproteins (metabolism), Neovascularization, Pathologic (physiopathology), Stem Cells (physiology).
MESH :
- chemical , metabolism : Membrane Glycoproteins.
- cytology : Bone Marrow Cells.
- physiology : Endothelial Cells, Lymphatic Vessels, Stem Cells.
- physiopathology : Neovascularization, Pathologic.
- Humans.

Abstract

The lymphatic vasculature plays a pivotal role in maintaining tissue fluid homeostasis, immune surveillance, and lipid uptake in the gastrointestinal organs. Therefore, impaired function of the lymphatic vessels caused by genetic defects, infection, trauma, or surgery leads to the abnormal accrual of lymph fluid in the tissue and culminates in the swelling of affected tissues, known as lymphedema. Although millions of people suffer from lymphedema worldwide which causes impaired wound healing, compromised immune defense and, in rare case, lymphangiosarcoma, no effective therapy is currently available. In addition, recent advances in cancer biology have disclosed an indispensable function of the lymphatic vessel in tumor growth and metastasis. Therefore, understanding the detailed mechanisms governing lymphatic vessel formation and function in pathophysiologic conditions is essential to prevent or treat these diseases. Here, we will review the developmental processes of the lymphatic vessels and postnatal lymphatic neovascularization, focusing on the role of recently identified bone-marrow (BM) derived PODOPLANIN expressing (PODOPLANIN⁺) cells as lymphatic endothelial progenitor cells (LEPCs).

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384483

DOI: 10.1016/j.tcm.2012.04.002
PubMed: 22732548
PubMed Central: 3384483

Affiliations:

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<front><div type="abstract" xml:lang="en"><p id="P2">The lymphatic vasculature plays a pivotal role in maintaining tissue fluid homeostasis, immune surveillance, and lipid uptake in the gastrointestinal organs. Therefore, impaired function of the lymphatic vessels caused by genetic defects, infection, trauma, or surgery leads to the abnormal accrual of lymph fluid in the tissue and culminates in the swelling of affected tissues, known as lymphedema. Although millions of people suffer from lymphedema worldwide which causes impaired wound healing, compromised immune defense and, in rare case, lymphangiosarcoma, no effective therapy is currently available. In addition, recent advances in cancer biology have disclosed an indispensable function of the lymphatic vessel in tumor growth and metastasis. Therefore, understanding the detailed mechanisms governing lymphatic vessel formation and function in pathophysiologic conditions is essential to prevent or treat these diseases. Here, we will review the developmental processes of the lymphatic vessels and postnatal lymphatic neovascularization, focusing on the role of recently identified bone-marrow (BM) derived PODOPLANIN expressing (PODOPLANIN<sup>+</sup>
) cells as lymphatic endothelial progenitor cells (LEPCs).</p>
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Serveur d'exploration sur le lymphœdème

Role of bone marrow-derived lymphatic endothelial progenitor cells for lymphatic neovascularization

Role of bone marrow-derived lymphatic endothelial progenitor cells for lymphatic neovascularization

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
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